Cancer element12/10/2023 With collaborators in Spain, DCEG investigators evaluated DBP in relation to bladder cancer risk in the Interdisciplinary Case-Control Study of Bladder Cancer in Spain, considering exposure via ingestion, showering/bathing, and swimming in pools. Studies indicate that dermal and inhalation exposures to trihalomethanes (THM), a major component of DBPs in treated water, can be significant. Laura Beane Freeman and Rena Jones studied bladder and endometrial cancer risk, respectively. ![]() The data from these and additional cancer sites included in the study are under evaluation following an improved historical exposure assessment effort in which DBP exposures were estimated for each individual water utility, taking into account changes in water source and treatments over time.ĭrinking water contaminants and cancer risk ![]() A DCEG study of six cancer sites conducted in Iowa found associations of rectal and bladder cancers with long-term (>40 years) exposure to drinking water high in these unintentional byproducts. Although concentrations in the United States are quite low, there is concern that some chemicals in the mixture may increase cancer risk. Debra Silverman.Ĭhlorine interacts with organic materials in water to form a mixture of DBPs. Cumulative arsenic exposure from all water sources demonstrated a dose-response relationship with bladder cancer.įor more information, contact Dr. Exposure to arsenic and other drinking water contaminants (i.e., DBP and nitrates) was assessed based on drinking water samples taken at current and former homes, monitoring data obtained from public water utilities, and a geographic information system (GIS)-based predictive model based on geologic characteristics at the wells when measurements were missing. Bladder cancer risk increased with increasing water intake, with significant trends observed among participants with a history of private well use, whose well water was exclusively sourced from shallow dug wells, or who used dug wells prior to 1960, when arsenical pesticides were widely used in the regions. Large populations are needed to adequately characterize bladder cancer risk from lower levels of arsenic exposure in drinking water. DCEG investigators conducted the New England Bladder Cancer Study, a population-based case-control study in Maine, New Hampshire, and Vermont, to identify risk factors that might explain the persistent high rates in these states, to evaluate exposure to arsenic at low to moderate levels, and to evaluate possible gene-exposure interactions. ![]() Ingestion of high levels of arsenic is an accepted cause of bladder cancer, but risk at lower levels is uncertain. Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Risk of Cancer
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